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Dr. Stacy Sims11 July 2025

Episode 466: Dr. Stacy Sims: Why Women Can't Fast Like Men + The Training Intensity You Should Avoid

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The myth-busts, hot takes, explainers, and tools worth keeping.

Myth Buster· 2

Myth Buster11:30

Plant Protein Does Not Need to Be Complete at Every Meal

Sims rejects the idea that every plant-based meal must contain a complete protein. What matters is total daily protein, coverage of essential amino acids, and enough post-exercise leucine; pea protein isolate may require a slightly larger dose than whey.

  • Complete proteins are not required at every individual meal
  • Total daily protein and essential amino acids are the main targets
  • Leucine content matters after exercise
  • Pea protein isolate may need a larger serving than whey

it's not about that it's about the total amount of protein you have through the day and making sure that you have all your essential…

Dr. Stacy Sims · 11:30

So you have a little bit of a bigger dose of the pea protein than you would the whey.

Dr. Stacy Sims · 12:00
#plant protein#leucine#amino acids#muscle
Myth Buster15:30

Why Beet Juice May Help After Menopause but Hurt Before It

Sims says nitrate-rich beet juice can improve vasodilation and VO2 max in post-menopausal women. Before menopause, including perimenopause, added nitrates may disrupt an estrogen-linked vascular system and contribute to poor blood-pressure control.

  • Supplement effects can change across menopausal status
  • Beet juice may improve vasodilation and VO2 max after menopause
  • Estrogen is closely tied to vascular nitric-oxide regulation before menopause
  • Added nitrates may contribute to orthostatic hypotension in premenopausal women

For post-menopausal women, sweet, it works well. It helps with vasoddilation. It helps improve V2 max.

Dr. Stacy Sims · 15:30

But for uh premenopausal women, including pmenopause, it has a a backwards effect because we have estrogen that's tightly tied to our vessels

Dr. Stacy Sims · 16:00
#beet juice#menopause#vasodilation#blood pressure

Hot Take· 1

Hot Take16:30

Why Sims Is Cautious About Beta-Alanine for Women

Sims says the evidence is not yet clear enough to describe beta-alanine as reliably beneficial for women. Her preference is to begin with well-supported foundational supplements and assess additional products individually.

  • Performance-supplement evidence is often not female-specific
  • Beta-alanine may or may not benefit women
  • An unclear evidence base should limit blanket recommendations
  • Individual assessment follows the foundational supplements

and then things like beta alanine. it may or may not have an effect for women.

Dr. Stacy Sims · 16:30

So, it's kind of in the there's not enough to elucidate the evidence for to be pro- women.

Dr. Stacy Sims · 16:30
#beta-alanine#supplements#women's research

Explainer· 2

Explainer07:00

Why Women's Low-Energy Threshold Is Higher Than Men's

Sims says female hypothalamic sensitivity to nutrient availability differs substantially from men's because of reproductive biology. She gives 35 calories per kilogram of fat-free mass as a bare minimum for women, ideally closer to 40, compared with a disturbance threshold around 15 for men.

  • Female hypothalamic pathways are especially sensitive to nutrient density
  • Low availability can affect thyroid, appetite hormones, sleep, and body composition
  • Sims cites 35 calories per kilogram of fat-free mass as the female minimum
  • The corresponding male disturbance threshold is much lower

women need a bare minimum of 35 calories per kilogram of fat-free mass to be able to maintain some endocrine health.

Dr. Stacy Sims · 07:30

When you start to drop below that 35 for women, we start to see a lot of dis subclinical disturbance in indocrine and sleep and…

Dr. Stacy Sims · 08:00
#energy availability#endocrine health#sex differences
Explainer09:30

Why Women's Protein Needs Rise From Around Age 40

Women become more resistant to the muscle-building effects of exercise and protein from around age 40, according to Sims, while the comparable shift in men begins later. Active adults therefore need more protein and a stronger resistance-training stimulus than malnutrition-prevention guidance implies.

  • Anabolic resistance begins earlier in women than men
  • More protein must be paired with a stronger resistance-training dose
  • Minimum public guidance is designed to prevent malnutrition, not optimize active adults
  • Sims suggests one to 1.1 grams per pound for active people pursuing lean mass

We see that when women start to hit 40 onwards, we are more what's called anabolically resistant to exercise and protein.

Dr. Stacy Sims · 09:30

For men, that starts about 50 55.

Dr. Stacy Sims · 09:30
#protein#muscle#aging#resistance training

Story· 1

Story00:00

Why Stacy Sims Has Been Plant-Based Since Age 15

Sims traces her long-term plant-based diet to a teenage field trip to a pig slaughterhouse. She says maintaining it was harder before plant-based foods and guidance became widely available.

  • A slaughterhouse visit changed her relationship with animal protein
  • She adopted the diet long before modern plant-based options were common
  • The experience still affects her ability to eat eggs or fish

when I was 15, we took a field trip to a pig's slaughter house down the five.

Dr. Stacy Sims · 00:00

I had issues back in the day cuz there was no such thing as plant-based and so I've kind of fought my way through but…

Dr. Stacy Sims · 00:30
#plant-based#nutrition#personal story

Tool· 1

Tool13:00

The Plant Protein Sources Sims Recommends Most

Sims highlights tempeh, spirulina, pea protein isolate, and fortified non-dairy yogurts as practical protein sources. She also argues that the carbohydrates and fiber accompanying many plant foods help address needs that isolated animal protein does not cover.

  • Tempeh, spirulina, and pea protein isolate are high-priority options
  • Fortified almond or coconut yogurt can contribute substantial protein
  • Plant sources also supply fiber for gut-microbiome diversity
  • Women often undereat carbohydrates rather than consuming too much

Yeah, spirulina is really good in iron and protein.

Dr. Stacy Sims · 13:00

if we're looking at the plant-based proteins, we're also getting a lot of fiber, which is really super important for our gut microbiome.

Dr. Stacy Sims · 13:30
#plant protein#fiber#gut health#carbohydrates

Takeaway· 1

Takeaway14:30

Sims' Three Foundational Supplements for Women

Sims prioritizes creatine monohydrate, omega-3 fatty acids, and vitamin D3 before more individualized supplements. She connects them respectively to broad tissue support, cellular and antioxidant capacity, and system-wide functions including iron absorption.

  • Creatine monohydrate is Sims' first choice
  • Omega-3 fatty acids support antioxidant and cellular capacity
  • Vitamin D3 has system-wide roles and supports iron absorption
  • Other supplements should be considered individually after the foundational three

So there I would say the big three would be uh creatine monohydrate for sure

Dr. Stacy Sims · 14:30

So those would be the top three and then of course you can add things like um your adaptogens if you want your protein powders…

Dr. Stacy Sims · 15:30
#supplements#creatine#omega-3#vitamin d